Main Goals in the Management of NF1-PN

EP: 1.Genetic And Molecular Mechanisms of NF1

EP: 2.Diagnosis, Epidemiology, And Risk Factors Of NF1-PN

EP: 3.Hallmark Symptoms and Clinical Features of NF1-PN

EP: 4.Quality of Life in Patients With NF1-PN

EP: 5.Key Clinical Considerations in NF1-PN Management

EP: 6.Unmet Needs of Patients Living With NF1-PN

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EP: 7.Main Goals in the Management of NF1-PN

EP: 8.Rationale for MEK Inhibitors and Surgery

EP: 9.Selumetinib as a Therapeutic Option for NF1-PN

EP: 10.Examining Combination Therapy In NF1-PN

EP: 11.Barriers to Optimal NF1-PN Care for Patients

Summary for Physicians

Current Management Goals for NF1-PN

The primary goals in managing neurofibromatosis type 1–associated plexiform neurofibromas (NF1-PN) are to control tumor growth, manage symptoms (pain, disfigurement, neurological impairment), and prevent malignant transformation. Treatment strategies focus on monitoring tumor progression, surgical resection when feasible, and symptomatic management (eg, pain relief, functional support).

Future Evolving Goals

As research advances, future management may focus on targeted therapies aimed at the molecular drivers of NF1-PN, such as RAS/MAPK pathway inhibitors or gene therapies. Additionally, there is potential for earlier intervention with personalized treatment plans based on genetic profiling. Enhanced early detection and preventive strategies for malignancy may also become key components of care.